The Ampoule is an obtainable item in Silent Hill, Silent Hill 2, Silent Hill 3, Silent Hill 4: The Room, and Silent Hill: Origins. The ampoule is a rare and powerful healing item in the games they appear in. It will completely heal the playable protagonist, with the exception of Silent Hill 4: The Room. In Silent Hill 3, the ampoule also restores Heather Mason's stamina.
The word "ampoule" refers to a small glass vial, most often referring to the small vials that contain hypodermic solutions. In Silent Hill, ampoules come with a hypodermic needle with which to administer the solution. The solution in the series is not directly identified, but its effects include limited tissue regeneration, increased clotting, energy increasing effects, and powerful pain-killers.